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. 2021 Mar 23;11(3):191. doi: 10.3390/metabo11030191

Figure 5.

Figure 5

Carnitine rescues cardiac function in diabetes after low-flow ischemia in Langendorff perfused hearts. (A) Rate pressure product (RRP) over time: pre-ischemia (t = 1:20 min), low flow ischemia (t = 21:50 min), post ischemia (t = 51:80 min). (B) Rate pressure product (RRP) pre-ischemia. (C) Rate pressure product (RRP) post-ischemia. (D) Percentage recovery between pre-ischemia (t = 10:20 min) and post-ischemia (t = 70:80 min). (E) Difference between post-ischemia and pre-ischemic diastolic pressure (∆DiaP). Diastolic pressure was set during pre-ischemia to 4–8 mmHg. Data are presented as mean ± SD. Two-way ANOVA, if an interaction was found to be significant, the effect of L-carnitine on control and diabetes was evaluated using Sidak’s multiple comparison test. Significant differences are represented by ‘*’, with * p < 0.05, ** p < 0.01, **** p < 0.0001.