AD	Alzheimer’s disease
Aβ	Amyloid-β peptide
Bcl-2	B-cell lymphoma 2
BDNF	Brain-derived neurotrophic factor
cAMP	Cyclic adenosine monophosphate
CNS	Central nervous system
COPD	Chronic obstructive pulmonary disease
CR3	Control region 3
CREB	cAMP response element binding protein
ele	electrostatic interactions
Epac1/2	Exchange factor directly activated by cAMP 1 and 2
ESP	Electrostatic potential
FDA	Food and Drug Administration
FEP	Free energy perturbation
GAFF	General AMBER force field
HF	Hartree-Fock
IBD	Inflammatory bowel diseases
IL-1β	Interleukin 1 beta
IL-6	Interleukin 6
LIE	Linear interaction energy
LRA	Linear response approximation
LRF	Local reaction field
MD	Molecular dynamics
PDB	Protein data bank
PDE4	Phosphodiesterase 4
PKA	Protein kinase A
RA	Rheumatic arthritis
RESP	Restricted electrostatic charge fitting procedure
PLIP	Protein ligand interaction profiler
RMR6	Radial-mean-reduced scoring function at a cutoff radius of 6 Å from each atom of the ligand
RMSD	Root mean square deviation
RMSF	Root mean square fluctuation
ROS	Reactive oxygen species
SCAAS	Surface constraint all-atom solvent
UCR1	Upstream conserved region 1
UCR2	Upstream conserved region 2
vdW	van der Waals interactions