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SIN-1 affects the intracellular COX-2 localization. HUVEC unstimulated or treated with IL-1α or SIN-1 alone or in combination for 18 h, were fixed in 2% paraformaldehyde and stained for COX-2 (in red). Nuclei (in blue) were visualized by Hoechst 33258. Images (400 x magnification) are representative of 3 independent experiments.
