Table 3.
Genotype frequencies comparisons across populations.
| Gene (SNP) * | Genotype | EUR (Reference) % (n) |
ASW % (n) |
CHS % (n) |
JPT % (n) |
MXL % (n) |
|---|---|---|---|---|---|---|
|
ABCG2 (rs2231142 G > T) |
GG GT TT |
82.3 (414) 16.5 (83) 1.2 (6) |
85.2 (52) 14.8 (9) — |
56.2 (59) * 36.2 (38) 7.6 (8) |
43.3 (45) * 49 (51) 7.7 (8) |
64.1 (41) * 31.2 (20) 4.7 (3) |
|
SLC2A9 (rs734553 T > G) |
GG GT TT |
5.6 (28) 38.7 (190) 56.7 (285) |
24.6 (15) * 44.3 (27) 31.1 (19) |
— 2.9 (3) * 97.1 (102) |
— 1 (1) * 99 (103) |
17.2 (11) 42.2 (27) 40.6 (26) |
|
SLC17A1 (rs1183201 T > A) |
AA AT TT |
23.1 (116) 46.1 (232) 30.8 (155) |
1.6 (1) * 2.13 (13) 77 (47) |
1.9(2) * 20 (21) 78.1 (82) |
3.8 (4) * 25 (26) 71.2 (74) |
10.9 (7) 37.5 (24) 51.6 (33) |
|
SLC16A9 (rs1171614 C > T) |
TT CT CC |
5.8 (29) 36.8 (185) 57.5 (289) |
4.9 (3) 36.1 (22) 59 (36) |
— — 100 (105)* |
— — 100 (104) * |
— 20.3 (13) 79.7 (51) |
|
GCKR (rs1260326 C > T) |
TT CT CC |
15.7 (79) 50.7 (255) 33.6 (169) |
80.3 (49) * 19.7 (120) — |
20 (21) 60 (63) 20 (21) |
35.6 (37) * 45.2 (47) 19.2 (20) |
14.1 (9) 42.2 (27) 43.8 (28) |
|
SLC22A11 (rs2078267 C >T) |
CC CT TT |
23.9 (120) 46.1 (232) 30 (151) |
72.1 (44) * 26.2 (16) 1.6 (1) |
96.2 (10) 3.8 (4) — |
96.2 (100) * 3.8 (4) — |
60.9 (39) * 29.7 (19) 9.4 (6) |
|
SLC22A12 (rs505802 C > T) |
TT CT CC |
51.3 (258) 38.8 (195) 9.9 (50) |
13.1 (8) * 44.3 (27) 42.6 (26) |
6.7 (7) * 32.4 (34) 61 (64) |
1 (1) * 33.7 (35) 65.4 (68) |
23.4 (15) 53.1 (34) 23.4 (15) |
|
INHBC (rs3741414 C > T) |
CC CT TT |
65 (327) 31 (156) 4 (20) |
75.4 (46) 23 (14) 1.6 (1) |
83.8 (88) 15.2 (16) 1 (1) |
89.4 (93) * 9.6 (10) 1 (1) |
29.7 (19) * 46.9 (30) 23.4 (15) |
|
RREB1 (rs675209 T > C) |
TT CT CC |
8.5 (43) 36.8 (185) 54.7 (275) |
19.7 (12) 45.9 (28) 34.4 (21) |
84.8 (89) * 13.3 (14) 1.9 (2) |
85.6 (89) * 13.5 (14) 1 (1) |
23.4 (15) 48.4 (31) 28.1 (81) |
|
PDZK1 (rs10910845 G > T) |
TT GT GG |
26.6 (134) 45.3 (228) 28 (141) |
52.5 (32) * 42.6 (26) 4.9 (3) |
71.4 (75) * 24.8 (26) 3.8 (4) |
89.4 (93) * 9.6 (10) 1 (1) |
35.9 (23) 45.3 (29) 18.8 (12) |
|
NRXN2 (rs478607 G > A) |
GG GA AA |
2.6 (13) 25.6 (129) 71.8 (361) |
19.7 (12) * 54.1 (33) 26.2 (16) |
3.8 (4) 26.7 (28) 69.5 (73) |
4.8 (5) 39.4 (41) 55.8 (58) |
4.7 (3) 17.2 (11) 78.1 (50) |
* Bold letter allele indicates the risk allele, which is defined as the allele that is associated with baseline or higher risk for HU or gout. * Indicates statistical significance p < 0.0045 between population of interest and reference group (EUR). EUR: European, ASW: Africans in Southwest U.S.; CHS: Southern Han-Chinese; JPT: Japanese in Tokyo; MXL: Mexicans in Los Angeles, CA, USA.