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. 2021 Mar 23;13(3):1037. doi: 10.3390/nu13031037

Figure 6.

Figure 6

Modulation of hepatic gene expressions involved in lipid biosynthesis by the diet. Mice were fed low-fat diet (LFD) supplemented with cellulose (LFDc, black bars) or inulin (LFDi, hatched black bars), or high-fat diet (HFD) supplemented with cellulose (HFDc, green bars) or inulin (HFDi, hatched green bars) for 11 weeks. (a) Hepatic expression of genes encoding enzymes involved in the desaturation of fatty acids: acyl-CoA desaturase 1 (Scd1), acyl-CoA (8-3)-desaturase (Fads1) and acyl-CoA 6-desaturase (Fads2). (b) Hepatic expression of genes encoding enzymes involved in the elongation of fatty acids: elongation of very long chain fatty acids proteins 1, 2, 3, 5 and 6 (Elovl1, Elovl2, Elovl3, Elovl5 and Elovl6). The levels of mRNA were normalized to Hprt mRNA level for calculation of the relative levels of transcripts. mRNA levels are illustrated as fold change. Data are presented as mean ± SEM (n = 10-12 in each group). * p < 0.05, ** p < 0.01 and **** p < 0.0001.