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. 2021 Mar 22;10(3):704. doi: 10.3390/cells10030704

Figure 1.

Figure 1

Schematic representation of KRIT1 protein. KRIT1 consists of a Nudix domain, three NPxY/F sites, four ankyrin repeat domains, and a FERM domain. FERM contains three subdomains (F1, F2, and F3) and each of them folds differently—F1 adopts a ubiquitin-like fold, F2 adopts an acyl–CoA binding protein fold, and F3 adopts a PTB domain-like fold. Colored forms and lines in the figure indicate domains and interactions required to bind CCM2 in order to build the CCM trimeric complex. Dotted lines indicate intermolecular interactions that may occur through each protein domain.