Table 1.
Inhibitory properties of BbCI, rBbCI, BbKI, rBbKI, and EcTI (Kiapp values are shown in nM).
| Enzyme | BbCI | rBbCI | BbKI | rBbKI | EcTI |
|---|---|---|---|---|---|
| Trypsin | φ | φ | 20.00 | 28.00 | 0.88 |
| Chymotrypsin | φ | φ | 26.00 | ND | 1.11 |
| Plasmin | φ | φ | 330.00 | ND | 9.36 |
| HNE | 5.30 | 1.70 | φ | φ | 55.0 |
| Factor Xa | φ | ND | φ | ND | φ |
| Thrombin | φ | ND | φ | ND | ND |
| PKa | φ | φ | 2.40 | 2.00 | 6.15 |
| PoPK | φ | φ | 200.00 | 900.00 | φ |
| Cathepsin G | 160.00 | ND | φ | φ | ND |
| Cathepsin L | 0.22 | ND | φ | ND | ND |
| Cruzain | 0.30 | 0.30 | φ | φ | ND |
| Cruzipain | 1.30 | 1.20 | φ | φ | ND |
HNE: human neutrophil elastase; PKa: human plasma kallikrein; PoPK: porcine pancreatic kallikrein, φ: indicates a lack of measurable inhibition; ND: not determined.