Table 2.
Demographic and clinical characteristics of CD patients with SCC arising from perianal fistula.
| Patient No. | Biologics, Steroids, Immunomodulators | Past Surgery | Years from CD to Cancer Diagnosis | Years from Fistula to Cancer Diagnosis | HPV Status | Imaging |
|---|---|---|---|---|---|---|
| 1 | NA | NO | 3 | NA | NA | NA |
| 2 | NA | NO | 14 | NA | NA | NA |
| 3 | NO | NO | 4 | 0 | NA | CT |
| 4 | NA | NO | 30 | NA | NO | NA |
| 5 | NA | NO | 23 | NA | NO | NA |
| 6 | aza | NO | 15 | 15 | NA | NA |
| 7 | steroids, aza | APR | 23 | 16 | NA | CT |
| 8 | NA | NO | 10 | 3 | NA | NA |
| 9 | NA | fistulotomy, ileocolic resection | 3 | 10 | NA | NA |
| 10 | NA | NO | 10 | 11 | NA | NA |
| 11 | NA | Hartmann | 20 | 5 | NA | NA |
| 12 | NO | Ileo-cecal resection, colostomy | 33 | 33 | NA | CT |
| 13 | steroids | proctectomy | 12 | 3 | NA | CT |
| 14 | steroids | diverting colostomy | 19 | Unknown | NA | CT |
| 15 | NA | diverting colostomy | >30 | Unknown | NA | MR |
| 16 | steroids, aza | subtotal colectomy | 27 | 27 | HPV 6 DNA HPV 16 DNA | CT |
| 17 | NA | total proctocolectomy, vaginectomy, flap | 18 | 18 | Yes | MR, CT |
| 18 | NA | APR | 30 | 13 | No | MR, CT |
| 19 | NA | NO | 26 | NA | Yes | MR, CT |
| 20 | steroids, IFX | ileal resection, right hemicolectomy, ileostomy | 11 | 10 | NA | MR, CT |
| 21 | No | diverting colostomy | 20 | 20 | NA | MR |
| 22 | aTNF | NO | 13 | 4 | NA | NA |
| 23 | aTNF | NO | 33 | 7 | NA | NA |
| 24 | NO | NO | >10 | 0 | NA | NA |
| 25 | aTNF | NO | 25 | NA | NA | NA |
| 26 | NO | NO | 31 | 5 | NA | NA |
| 27 | aTNF | NO | 16 | 3 | NA | NA |
| 28 | NO | APR | >10 | NA | NA | NA |
| 29 | NO | TPC | 12 | NA | NA | NA |
| 30 | aTNF | NO | 48 | 14 | NA | NA |
| 31 | prednisone certolizumab |
several small bowel resections | 30 | NA | Yes | NA |
| 32 | NO | left colectomy and partial proctectomy; APR/VRAM for CD with incidental finding of ASCC | 20 | NA | Yes | NA |
| 33 | 6-MP | NO | 22 | NA | Yes | NA |
| 34 | MTX | EUA/seton | 14 | NA | Yes | NA |
| 35 | NO | proctocolectomy with ileostomy (1970’s) | 35 | NA | Yes | NA |
| 36 | NA | NO | 20 | NA | NO | CT |
aza: azathioprine; MTX: methotrexate; 6-MP: 6-mercaptopurine; IFX: infliximab; aTNF: anti-TNF; APR: abdominal perineal resection; TPC: total proctocolectomy; VRAM: right vertical rectus abdominis myocutaneous flap; EUA: exam under anesthesia; ASCC: anal squamous cell carcinoma; NA: not available, HPV: Human Papilloma Virus; MR: Magnetic Resonance; CT: Computed Tomography.