Table 3.

Clinical characteristics of CD patients with SCC derived from perianal fistula.

Patient No.	Stage	RT	CT	Residual Disease 6 Months	Surgery after CT-RT	Treatment of Recurrent Disease	Symptoms	Cancer Treatment	Outcome	Diagnosis
1	NA	Yes	No	No	colectomy and APR	No	pain	RT+colectomy+APR	Alive 2 y	NA
2	NA	No	No	No	No	RT	abscess	Subtotal Colectomy (1968) and APR 1982	Alive 1.5 y	NA
3	NA	No	No	NA	No	No	perianal mass	Right hemicolectomy, excision of anal lesion	Alive	biopsy
4	NA	Yes	No	Yes	proctectomy	No	severe pain	RT+proctectomy	Died 10 mo	biopsy
5	NA	Yes	No	No	No	No	diarrhea	RT	Died 2 y	EUA
6	NA	Yes	Yes	No	No	No	anal lump, anal stricture	CT+RT	Alive 6 mo	EUA
7	NA	Yes	No	NA	No	No	bleeding, perianal mass	RT	lost to FU	biopsy
8	NA	Yes	Yes	NA	No	No	severe pain	CT+RT	Died 6 mo	EUA
9	NA	Yes	Yes	NA	excision	local excision	persistent fistula	CT+RT+excision	Alive	biopsy
10	NA	Yes	Yes	NA	APR	No	severe pain	CT+RT+APR	Alive	biopsy
11	NA	Yes	Yes	NA	APR	No	severe pain	CT+RT+APR	Died 1.5 y	biopsy
12	NA	No	No	No	No	local excision	perianal mass	debridement, proctectomy	Died 9 mo	surgery
13	NA	Yes	Yes	No	ileostomy	RT	NA	CT+RT+Proctectomy	Alive 6 y	surgery
14	NA	No	No	NA	NA	NA	pus discharge	Debridement	lost to FU	biopsy
15	NA	No	No	No	No	No	septic shock	No treatment	Died	biopsy
16	II	Yes	Yes	No	APR	local excision	pus discharge	APR	NA	biopsy
17	IV	Yes	Yes	NA	No	NA	pain	CT+RT+TPC	Alive 26 mo	surgery
18	II	Yes	Yes	NA	No	NA	pain	CT+RT+APR	Died 23 mo	surgery
19	II	Yes	No	No	APR, vaginectomy, flap	NA	pain	RT+APR	Alive 37 mo	biopsy
20	NA	Yes	Yes	Yes	No	No	severe anal stricture, pain	CT+RT	NA	biopsy
21	NA	No	No	No	No	No	perianal abscess	none	Died 3 mo	biopsy
22	NA	Yes	Yes	NA	No	No	asymptomatic chronic fistula	CT+RT	NA	biopsy
23	NA	Yes	Yes	NA	No	No	increasing pain and drainage	CT+RT	NA	biopsy
24	NA	Yes	Yes	NA	APR	No	increasing pain and drainage	CT+RT+APR	NA	biopsy
25	NA	Yes	Yes	NA	APR	No	unknown	CT+RT+APR	NA	biopsy
26	NA	Yes	Yes	NA	No	No	increasing pain and ulceration	CT+RT	NA	biopsy
27	NA	Yes	Yes	NA	No	No	asymptomatic chronic fistula	CT+RT	NA	biopsy
28	NA	Yes	Yes	NA	No	No	unknown	APR+CT+RT	NA	biopsy
29	NA	Yes	Yes	NA	No	No	unknown	TPC+RT+CT	NA	biopsy
30	NA	No	No	NA	No	No	increasing pain, severe sepsis	No treatment	Died 1 y	biopsy
31	IIIB	Yes	Yes	No	APR/VRAM (for CD, no recurrence)	NA	perianal pain	RT+CT+APR	Alive 5 y	biopsy
32	IIIA	Yes	Yes	NA	No	CT-RT	bleeding	CT+RT	Died 6 mo	biopsy
33	I	Yes	Yes	No	No	NA	perianal pain	CT+RT	Alive 5 y	biopsy
34	NA	Yes	Yes	Yes	APR	NA	perianal pain	CT+RT+APR	NA	biopsy
35	IV	Yes	Yes	Yes	APR/VRAM IORT	Chemotherapy	perianal pain	CT+RT+APR+IORT	Died 6 mo	biopsy
36	NA	NA	NA	NA	NA	NA	discharge of stool through perianal fistulas, weight loss	APR, excision of perineal tumor	NA	biopsy

CT-RT: chemoradiation; RT: radiotherapy; CT: chemotherapy; APR: abdominal perineal resection; VRAM: right vertical rectus abdominis myocutaneous flap; IORT: intraoperative radiotherapy; mo: months; FU: follow-up.