Table 2.
Laboratory findings of the study patients*
| Indicators | Normal range | Total |
Non-sudden deaths |
Sudden deaths |
P value | |||
|---|---|---|---|---|---|---|---|---|
|
inflammatory factors: | ||||||||
| Procalcitonin, ng/mL |
<0.05 |
N = 261 |
0.29 (0.12-0.89) |
N = 240 |
0.23 (0.12-0.88) |
N = 21 |
0.54 (0.36-1.11) |
0.029 |
| CRP, mg/L |
<1.0 |
N = 276 |
105.60 (59.33-164.43) |
N = 250 |
100.65 (57.12-161.07) |
N = 26 |
151.35 (122.40-202.02) |
0.001 |
|
Cytokines: | ||||||||
| IL-6, pg/mL |
0.0-7.0 |
N = 202 |
61.34 (29.27-151.45) |
N = 193 |
59.69 (26.56-141.90) |
N = 9 |
146.80 (63.03-158.90) |
0.145 |
| IL-10, pg/mL |
0.0-9.1 |
N = 199 |
10.30 (6.35-18.70) |
N = 191 |
10.40 (6.30-18.55) |
N = 8 |
9.25 (6.70-23.70) |
0.895 |
| IL-8, pg/mL |
0.0-62.0 |
N = 200 |
28.40 (16.35-61.82) |
N = 192 |
28.35 (16.15-63.52) |
N = 8 |
30.55 (20.33-38.88) |
0.884 |
| IL-1β, pg/mL |
0.0-5.0 |
N = 200 |
5.00 (5.00-6.93) |
N = 192 |
5.00 (5.00-7.03) |
N = 8 |
5.00 (5.00-5.00) |
0.248 |
| IL-2R, U/mL |
223.0-710.0 |
N = 198 |
1148.0 (740.3-1615.0) |
N = 190 |
1126.0 (731.8-1599.3) |
N = 8 |
1340.5 (1067-1782.25) |
0.346 |
|
Blood routine: | ||||||||
| Leucocytes count, ×109/L |
3.50-9.50 |
N = 281 |
8.91 (6.00-13.03) |
N = 253 |
8.46 (5.73-12.89) |
N = 28 |
11.27 (8.68-17.90) |
0.011 |
| Erythrocytes count, ×1012L |
4.30-5.80 |
N = 281 |
4.17 (3.60-4.63) |
N = 253 |
4.17 (3.61-4.62) |
N = 28 |
4.19 (3.52-4.70) |
0.822 |
| Monocytes, % |
3.0-10.0 |
N = 281 |
4.60 (2.70-7.50) |
N = 253 |
4.90 (2.80-8.00) |
N = 28 |
3.30 (2.58-4.25) |
0.003 |
| Monocytes count, ×109/L |
0.10-0.60 |
N = 281 |
0.40 (0.26-0.62) |
N = 253 |
0.40 (0.27-0.63) |
N = 28 |
0.42 (0.24-0.54) |
0.753 |
| Neutrophils, % |
40.0-75.0 |
N = 281 |
87.10 (79.90-92.20) |
N = 253 |
86.70 (79.10-92.20) |
N = 28 |
89.15 (86.88-92.40) |
0.036 |
| Neutrophils count, ×109/L |
1.80-6.30 |
N = 281 |
7.75 (4.53-11.63) |
N = 253 |
7.30 (4.49-11.54) |
N = 28 |
10.34 (7.70-15.83) |
0.006 |
| Eosinophils, % |
0.4-8.0 |
N = 281 |
0.00 (0.00-0.10) |
N = 253 |
0.00 (0.00-0.10) |
N = 28 |
0.00 (0.00-0.00) |
0.004 |
| N = 281 |
0.215 ± 0.686 |
N = 253 |
0.238 ± 0.719 |
N = 28 |
0.014 ± 0.052 |
|||
| Eosinophils count, ×109/L |
0.02-0.52 |
N = 281 |
0.00 (0.00-0.01) |
N = 253 |
0.00 (0.00-0.01) |
N = 28 |
0.00 (0.00-0.00) |
0.006 |
| N = 281 |
0.023 ± 0.086 |
N = 253 |
0.025 ± 0.090 |
N = 28 |
0.002 ± 0.006 |
|||
| Basophils, % |
0.0-1.0 |
N = 281 |
0.10 (0.00-0.20) |
N = 253 |
0.10 (0.00-0.20) |
N = 28 |
0.10 (0.08-0.12) |
0.545 |
| Basophils count, ×109/L |
0.00-0.10 |
N = 281 |
0.01 (0.00-0.02) |
N = 253 |
0.01 (0.00-0.02) |
N = 28 |
0.01 (0.01-0.02) |
0.423 |
| Hemoglobin, g/L |
130.0-175.0 |
N = 281 |
128.00 (112.00-143.00) |
N = 253 |
128.00 (111.00-143.00) |
N = 28 |
122.00 (112.75-142.25) |
0.761 |
| Platelets count, ×109/L |
125.0-350.0 |
N = 281 |
159.00 (111.00-224.00) |
N = 253 |
161.00 (112.00-224.00) |
N = 28 |
147.00 (87.75-223.50) |
0.580 |
|
Lymphocytes: | ||||||||
| Lymphocytes, % |
20.0-50.0 |
N = 281 |
7.10 (4.10-12.20) |
N = 253 |
7.20 (4.10-12.60) |
N = 28 |
6.90 (4.33-9.12) |
0.289 |
| Lymphocytes count, ×109/L |
1.10-3.20 |
N = 281 |
0.63 (0.44-0.85) |
N = 253 |
0.61 (0.43-0.84) |
N = 28 |
0.66 (0.51-0.90) |
0.23 |
| CD3+ T cell count/μL |
690-2540 |
N = 54 |
276.50 (132.75-408.50) |
N = 49 |
269.00 (130.00-404.00) |
N = 5 |
379.00 (332.00-448.00) |
0.395 |
| CD3+CD4+ T cell count/μL |
410-1590 |
N = 54 |
170.50 (93.25-257.50) |
N = 49 |
166.00 (93.00-243.00) |
N = 5 |
264.00 (253.00-275.00) |
0.257 |
| CD3+CD8+ T cell count/μL |
190-1140 |
N = 54 |
62.00 (29.25-127.00) |
N = 49 |
61.00 (29.00-124.00) |
N = 5 |
110.00 (56.00-158.00) |
0.447 |
| CD4+/CD8+ T cell count/μL |
1.02-1.94 |
N = 54 |
2.86 (1.82-4.72) |
N = 49 |
2.97 (1.83-4.79) |
N = 5 |
2.40 (1.79-3.95) |
0.633 |
| CD3-CD16+CD56+ NK cell count/μL |
88-64 |
N = 54 |
36.50 (16.00-74.75) |
N = 49 |
35.00 (16.00-74.00) |
N = 5 |
43.00 (26.00-114.00) |
0.665 |
| CD19+ B cell count/μL |
77-736 |
N = 54 |
73.50 (40.25-143.00) |
N = 49 |
69.00 (40.00-130.00) |
N = 5 |
168.00 (75.00-229.00) |
0.257 |
|
Coagulation profiles: | ||||||||
| APTT, s |
26.0-42.0 |
N = 250 |
40.25 (36.23-46) |
N = 229 |
40.10 (36.10-46.00) |
N = 21 |
42.10 (38.00-48.30) |
0.309 |
| PT, s |
10.0-15.0 |
N = 281 |
15.30 (14.30-16.90) |
N = 253 |
15.30 (14.10-16.70) |
N = 28 |
16.30 (14.90-20.18) |
0.016 |
| PT-INR |
0.8-1.2 |
N = 281 |
1.20 (1.10-1.37) |
N = 253 |
1.20 (1.09-1.35) |
N = 28 |
1.29 (1.16-1.72) |
0.017 |
| D-dimer, ug/mL |
<0.5 |
N = 275 |
4.10 (1.39-15.41) |
N = 247 |
3.36 (1.31-14.16) |
N = 28 |
7.96 (2.93-21.00) |
0.004 |
| Fibrinogen, g/L |
2.0-4.0 |
N = 248 |
4.85 ± 2.08 |
N = 227 |
4.88 ± 2.08 |
N = 21 |
4.57 ± 2.18 |
0.510 |
| PTA, % |
70.0-140.0 |
N = 281 |
75.00 (62.00-86.00) |
N = 253 |
76.00 (64.00-87.00) |
N = 28 |
67.50 (47.00-79.00) |
0.019 |
| TT, s |
11.0-17.0 |
N = 248 |
17.00 (15.80-19.10) |
N = 228 |
17.10 (15.88-19.10) |
N = 20 |
16.45 (15.75-18.38) |
0.545 |
|
Electrolytes: | ||||||||
| Potassium, mmol/L |
3.50-5.30 |
N = 281 |
4.33 (3.89-4.84) |
N = 253 |
4.33 (3.87-4.84) |
N = 28 |
4.29 (3.92-4.85) |
0.89 |
| Sodium, mmol/L |
137.00-147.00 |
N = 281 |
138.80 (135.40-142.70) |
N = 253 |
138.50 (134.80-142.40) |
N = 28 |
141.25 (137.10-144.40) |
0.054 |
| Chloridion, mmol/L |
90.00-110.00 |
N = 281 |
100.20 (96.20-104.30) |
N = 253 |
100.00 (96.20-104.00) |
N = 28 |
102.00 (97.17-106.10) |
0.21 |
| Calcium, mmol/L |
2.11-2.52 |
N = 281 |
2.06 (1.99-2.14) |
N = 253 |
2.06 (1.99-2.15) |
N = 28 |
2.04 (1.97-2.09) |
0.196 |
| PHOS, mmol/L |
0.85-1.51 |
N = 194 |
0.96 (0.75-1.28) |
N = 189 |
0.96 (0.75-1.28) |
N = 5 |
0.89 (0.77-1.43) |
0.799 |
| Magnesium, mmol/L |
0.73-1.06 |
N = 195 |
0.91 (0.82-1.02) |
N = 190 |
0.90 (0.82-1.01) |
N = 5 |
0.93 (0.87-1.03) |
0.490 |
|
Organ damage index: | ||||||||
| ALT, U/L |
≤41 |
N = 281 |
27.00 (18.00-42.00) |
N = 253 |
24.00 (17.00-41.00) |
N = 28 |
39.50 (28.50-60.00) |
0.001 |
| AST, U/L |
≤40 |
N = 281 |
41.00 (29.00-59.00) |
N = 253 |
40.00 (28.00-58.00) |
N = 28 |
60.00 (37.75-85.25) |
0.003 |
| GGT, U/L |
6-42 |
N = 281 |
39.00 (25.00-69.00) |
N = 253 |
38.00 (24.00-65.00) |
N = 28 |
50.50 (34.75-97.00) |
0.031 |
| Total bilirubin, μmol/L |
≤26 |
N = 281 |
12.30 (9.00-18.70) |
N = 253 |
12.30 (9.00-18.70) |
N = 28 |
12.00 (8.75-18.18) |
0.917 |
| Direct bilirubin, μmol/L |
≤8.0 |
N = 280 |
6.15 (4.40-9.60) |
N = 252 |
6.10 (4.40-9.30) |
N = 28 |
6.30 (4.42-10.40) |
0.630 |
| Indirect bilirubin, μmol/L |
≤16.8 |
N = 278 |
5.95 (4.10-8.40) |
N = 250 |
5.95 (4.23-8.40) |
N = 28 |
5.90 (3.53-8.25) |
0.747 |
| ALB, g/L |
35-52 |
N = 280 |
31.10 (28.00-34.20) |
N = 252 |
31.30 (27.98-34.32) |
N = 28 |
29.75 (28.17-31.72) |
0.157 |
| GLO, g/L |
20-35 |
N = 280 |
35.60 (31.48-39.05) |
N = 252 |
35.65 (31.30-39.05) |
N = 28 |
35.40 (33.40-39.10) |
0.571 |
| Total protein, g/L |
64-83 |
N = 280 |
66.50 (61.82-70.82) |
N = 252 |
66.45 (61.60-71.00) |
N = 28 |
66.60 (62.50-68.80) |
0.550 |
| ALB/GLO |
1.50-2.50 |
N = 280 |
0.86 (0.75-1.00) |
N = 252 |
0.87 (0.76-1.01) |
N = 28 |
0.84 (0.74-0.92) |
0.305 |
| Total bile acid, μmol/L |
≤10 |
N = 177 |
3.40 (1.70-6.50) |
N = 173 |
3.40 (1.70-6.50) |
N = 4 |
3.35 (1.38-6.12) |
0.726 |
| Creatinine, μmol/L |
45-84 |
N = 281 |
87.00 (67.00-114.00) |
N = 253 |
86.00 (67.00-113.00) |
N = 28 |
95.50 (64.75-119.00) |
0.760 |
| Urea, mmol/L |
3.1-8.8 |
N = 279 |
8.30 (5.60-12.90) |
N = 251 |
8.20 (5.60-12.80) |
N = 28 |
9.74 (5.68-13.33) |
0.405 |
| Uric acid, μmol/L |
142.8-339.2 |
N = 279 |
265.20 (194.00-371.50) |
N = 251 |
265.20 (189.50-373.50) |
N = 28 |
291.00 (222.75-335.25) |
0.421 |
| Total cholesterol, mmol/L |
<5.18 |
N = 279 |
3.33 (2.83-3.96) |
N = 251 |
3.33 (2.83-3.96) |
N = 28 |
3.25 (2.82-3.69) |
0.633 |
| Triglyceride, mmol/L |
0.56-1.7 |
N = 178 |
1.54 (1.18-2.19) |
N = 171 |
1.53 (1.18-2.17) |
N = 7 |
1.69 (1.12-2.19) |
0.991 |
| HDL-C, mmol/L |
0.82-1.96 |
N = 177 |
0.78 ± 0.25 |
N = 170 |
0.78 ± 0.25 |
N = 7 |
0.76 ± 0.32 |
0.854 |
| LDL-C, mmol/L |
0.8-3.36 |
N = 176 |
1.90 (1.43-2.53) |
N = 169 |
1.92 (1.43-2.54) |
N = 7 |
1.86 (1.56-2.28) |
0.797 |
| Glucose, mmol/L |
3.89-6.11 |
N = 275 |
7.84 (6.37-11.06) |
N = 249 |
7.71 (6.32-10.95) |
N = 26 |
8.95 (7.30-13.76) |
0.067 |
| LDH, U/L |
135-225 |
N = 277 |
504.00 (364.00-669.00) |
N = 251 |
489.00 (357.00-648.00) |
N = 26 |
619.00 (549.25-884.50) |
0.001 |
| Alkaline phosphatase, U/L |
35-105 |
N = 281 |
78.00 (60.00-107.00) |
N = 253 |
76.00 (59.00-102.00) |
N = 28 |
93.50 (69.75-166.00) |
0.007 |
| Choline esterase, U/L |
4000-12000 |
N = 181 |
4947.48 ± 1618.62 |
N = 177 |
4948.79 ± 1616.65 |
N = 4 |
4889.50 ± 1965.47 |
0.942 |
| NT-proBNP, pg/mL |
<350 |
N = 252 |
888.50 (362.75-2566.50) |
N = 233 |
843.00 (330.00-2401.00) |
N = 19 |
2044.00 (980.50-6315.00) |
0.008 |
| Myoglobin, ng/mL |
10-80 |
N = 178 |
237.20 (100.68-1200.00) |
N = 170 |
237.20 (100.68-1200.00) |
N = 8 |
258.10 (97.18-1150.88) |
0.952 |
| hs-cTnI, pg/mL |
<0.1 |
N = 261 |
35.30 (11.20-194.70) |
N = 239 |
31.10 (10.90-192.90) |
N = 22 |
65.00 (24.17-246.02) |
0.082 |
| Creatine kinase, U/L | 30-170 | N = 192 | 129.00 (69.75-332.75) | N = 184 | 127.50 (68.75-328.75) | N = 8 | 290.00 (107.50-788.25) | 0.153 |
CRP – C-reactive protein, IL-6 – interleukin 6, IL-10 – interleukin 10, IL-8 – interleukin 8, IL-1β - interleukin 1β, IL-2R – Interleukin 2 receptor, APTT – activated partial thromboplastin time, PT – prothrombin time, PT-INR – prothrombin time international normalized ratio, PTA – prothrombin activity, TT – thrombin time, ALT – glutamic-pyruvic transaminase, AST – glutamic-oxalacetic transaminase, GGT – gamma-glutamyl transferase, ABL – albumin, GLO – globulin, HDL-C – high density lipoprotein cholesterin, LDL-C – low density lipoprotein cholesterol, LDH – lactic dehydrogenase, NT-proBNP – N-terminal pro brain natriuretic peptide, hs-cTnI – high-sensitivity cardiac troponin I
*Continuous variables were described as median (interquartile range) or mean (± standard deviation). P values were calculated by Wilcoxon rank sum tests for skewed distributed data, and independent sample t tests for normal distributed data.