TABLE 2.
AYA HRQOL Measurement Challenges and Potential Solutions
| AYA HRQOL PRO Measures Need to Be… | PROMIS Provides… |
|---|---|
| Flexible | Fixed short forms or computer adaptive testing |
| Efficient | Minimal response burden by selecting the most relevant questions |
| Reliable | Includes questions that demonstrate high ability to differentiate among individual HRQOL levels |
| Age appropriate | Adult PROMIS questions are written at a ≤ sixth-grade reading level |
| Relevant | Wide range of HRQOL domains can be assessed by PROMISa |
| Comprehensible | Vetted through cognitive interviews with a diverse sample of individuals with respect to age, educational level, race and/or ethnicity, and health status |
| Interpretable | Uses easily interpretable T score metric with reference scores to the US general population |
| Translatable | Available in Spanish and other languages |
Abbreviations: AYA, adolescent and young adult; HRQOL, health-related quality of life; PRO, patient-reported outcome; PROMIS, Patient-Reported Outcomes Measurement Information System.
a
The PROMIS HRQOL domains overlap with the majority of important HRQOL domains for AYAs with the exception of financial burden, body image, and fertility and/or parenthood.