Table 1. The Clinicopathologic Factors Predicting the Prognoses in 317 IMA Patients.
| Characteristics | IMA (n = 317) | DFS | OS | ||
|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | ||
| Age (years), median (range) | 60 (30–82) | ||||
| < 60 (ref.) vs. ≥ 60 | 164 (51.7)/153 (48.3) | 1.071 (0.724–1.585) | 0.732 | 1.160 (0.728–1.847) | 0.532 |
| Sex | |||||
| Female (ref.) vs. male | 192 (60.6)/125 (39.4) | 1.664 (1.124–2.464) | 0.011 | 2.068 (1.296–3.302) | 0.002 |
| Smoking history | |||||
| Never (ref.) vs. smoking | 214 (67.5)/103 (32.5) | 1.399 (0.935–2.092) | 0.102 | 1.256 (0.775–2.036) | 0.355 |
| Surgery type | |||||
| Sublobar (ref.) vs. lobe | 53 (17.7)/261 (82.4) | 1.138 (0.667–1.944) | 0.635 | 0.912 (0.499–1.665) | 0.764 |
| Overall stage | < 0.001 | < 0.001 | |||
| I (ref.) vs. II | 220 (69.4)/54 (17.0) | 3.719 (2.273–6.087) | < 0.001 | 4.610 (2.547–8.345) | < 0.001 |
| I (ref.) vs. III | 220 (69.4)/43 (13.6) | 8.595 (5.383–13.723) | < 0.001 | 9.566 (5.467–16.740) | < 0.001 |
| VPI | |||||
| Absence (ref.) vs. presence | 214 (67.5)/103 (32.5) | 1.902 (1.282–2.820) | 0.001 | 2.089 (1.311–3.328) | 0.002 |
| Tumor size, mm, mean ± SD | 31.2 ± 22.3 | 1.244 (1.177–1.315) | < 0.001 | 1.267 (1.194–1.345) | < 0.001 |
CI = confidence interval, DFS = disease-free survival, HR = hazard ratio, IMA = invasive mucinous adenocarcinoma, OS = overall survival, ref = reference, VPI = visceral pleural invasion