Table 2. Pooled Analysis of the Included Studies Evaluating Efficacy (Random-Effects Model).
| Treatment Arm | Intracranial ORR | Intracranial DCR | Intracranial CR | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Proportion | OR (95% CI) | P | Proportion | OR (95% CI) | P | Proportion | OR (95% CI) | P | |
| ICI monotherapy | 15 (11–20) | REF | 26 (21–32) | REF | 6 (2–14) | REF | |||
| ICI combined with radiotherapy | 42 (31–54) | 1.32 (1.17–1.49) | < 0.01 | 85 (63–95) | 1.94 (1.72–2.18)* | < 0.01 | 6 (1–37) | 1.00 (0.99–1.01) | 0.99 |
| ICI combination therapy | 53 (44–61) | 1.48 (1.32–1.65) | < 0.01 | 57 (49–66) | 1.37 (1.16–1.63)* | < 0.01 | 23 (17–32) | 1.26 (1.05–1.50) | 0.02 |
| Total | 29 (18–43) | - | - | 54 (38–70) | - | - | 10 (5–18) | - | - |
Values are expressed as proportion (95% CI). OR was calculated based on indirect comparison. *Intracranial DCR was significantly higher when using ICI combined with radiotherapy compared to ICI combination therapy (OR [95% CI], 1.41 [1.20–1.67]; p < 0.01). CI = confidence interval, CR = complete response, DCR = disease control rate (proportion of the patients who were confirmed as CR, PR, or SD), OR = odds ratio, ORR = objective response rate (proportion of the patients who were confirmed as CR or PR), PR = partial response, REF = reference category, SD = stable disease