Table 1:

Erythroferrone, hepcidin and SF3B1 mutation as independent predictors of hyperferritinemia in low transfusion burden MDS patients. Erythroferrone, hepcidin, sTfR, number of RBC units per 8 weeks, and SF3B1 mutation were evaluated in the group of 60 patients receiving less than 4 RBC units per 8 weeks on the basis of ferritin with a cut-off value of 300 ng/ml. Parameters are indicated as means and 95% confidence intervals (95% CI) or ranges. For univariate analysis, Mann-Whitney and X² tests were used to compare the variables between SF3B1^MUT and SF3B1^WT MDS. Multivariate logistic regression analysis was performed for variables with P-value <0.100 in univariate analysis.

Parameters	Ferritin < 300 ng/ml	Ferritin ≥ 300 ng/ml	Univariate	Multivariate
	n = 19	n = 41	P-value	P-value
Erythroferrone (ng/ml), mean (95% CI)	36.7 (26.8 – 46.6)	72.7 (55.4 – 90.0)	0.005	0.002
Hepcidin (ng/ml), mean (95% CI)	17.2 (11.2 – 23.2)	35.9 (25.9 – 45.9)	0.013	<0.0001
sTfR (ng/ml), mean (95% CI)	1.21 (0.99 – 1.43)	1.42 (1.18 – 1.65)	0.484
Number of RBC units / 8 weeks, mean (range)	0.2 (0 – 2)	0.6 (0 – 3)	0.104
SF3B1 mutation yes, n (%)	3 (15.8)	22 (53.6)	0.006	0.023