Fig. 2. Mediation analysis of gene risk score difference in BMI by appetite-related traits in adults aged 45–65 years. (N = 2464).

The proportion of BMI differences according to genetic risk score explained by disinhibition and hunger was estimated by adding each appetite-related trait to a model for BMI, separately and simultaneously. The 95% confidence intervals for the mediation proportions were estimated using a bootstrap procedure. The model was adjusted for sex, linear and curvilinear age (age²), birth cohort effect on BMI, and the eating behavior *age interaction. Disinhibition level accounted for 33.7% (95% confidence interval 29.1–42.9%) of the GRS-BMI association.