Table 2.

GIQLI questionnaire domains

Question	Baseline	2 weeks	6 weeks	p value
How often during the past 2 weeks have you had pain in the abdomen? (GIQLI #1)	1.73 ± 0.85	1.50 ± 0.68	1.35 ± 0.64a	< 0.001
How often during the past 2 weeks have you had bloating (sensation of too much gas in the abdomen)? (GIQLI #3)	2.02 ± 0.90	1.84 ± 0.63	1.34 ± 0.56a	< 0.001
How often during the past 2 weeks have you been troubled by frequent bowel movements? (GIQLI #7)	1.66 ± 0.77	1.75 ± 0.70	1.52 ± 0.67	< 0.001
How often during the past 2 weeks have you been troubled by urgent bowel movements? (GIQLI #30)	1.37 ± 0.71	1.58 ± 0.78	1.27 ± 0.66	< 0.001
How often during the past 2 weeks have you been troubled by diarrhea? (GIQLI #31)	1.39 ± 0.77	1.70 ± 0.77a	1.53 ± 0.72	< 0.001
How often during the past 2 weeks have you been troubled by constipation? (GIQLI #32)	1.98 ± 0.97	1.29 ± 0.69a	1.24 ± 0.61a	< 0.001
How often during the past 2 weeks have you been troubled by nausea? (GIQLI #33)	1.42 ± 0.79	1.25 ± 0.68	1.03 ± 0.46a	< 0.001
How often during the past 2 weeks have you been troubled by uncontrolled stools? (GIQLI #36)	1.02 ± 0.58	1.03 ± 0.51	0.98 ± 0.47	0.08
Total score	12.50 ± 4.16	12.10 ± 3.36	9.47 ± 3.70a	< 0.001

Score: “0 = never”, “1 = rarely”, “2 = sometimes”, “3 = most of the time”, “4 = all the time”

^aClinical significant changes according to the ERES (empirical rule effect-size) method