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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J AAPOS. 2020 Nov 16;24(6):354.e1–354.e6. doi: 10.1016/j.jaapos.2020.07.016

FIG 2.

FIG 2.

Example of eyes that progressed from pre-plus to plus in 2 weeks (A) and a pre-plus eye that did not progress to plus in 3 weeks (B). Plus disease was defined as severe dilation and tortuosity of arterioles and venules that was equal to or greater than that of the reference images of the International Classification of Retinopathy of Prematurity (ICROP) in two or more quadrants; pre-plus disease, as vascular dilation or tortuosity that was not normal yet insufficient for the diagnosis of plus disease based on the ICROP reference images.