Table 3.

Ocular characteristics at the first detection of pre-plus and associations with progression from pre-plus to plus disease based on image evaluation

Ocular characteristics at first detection of pre-plus	Eyes with pre-plus disease, no., n = 681	Eyes progressed from pre-plus to plus disease, no. (%), n = 54	P value
Number of quadrants with pre-plus			<0.0001
1	424	17 (4.0%)
2	248	33 (13.3%)
4	9	4 (44.4%)
PMA weeks at the first detection of pre-plus			0.02
32	57	10 (17.5%)
33	124	10 (8.1%)
34	104	6 (5.8%)
35	126	12 (9.5%)
36	104	8 (7.7%)
37	64	5 (7.8%)
>37	102	23 (2.9%)
Stage at the first detection of pre-plus			<0.0001
No ROP	206	5 (2.4%)
Stage 2	222	17 (7.7%)
Stage 3	253	32 (12.6%)
Zone at the first detection of pre-plus			<0.0001
No ROP	206	5 (2.4%)
Zone II ROP	391	29 (7.4%)
Zone I ROP	84	20 (23.8%)
Combination of stage and zone at the first detection of pre-plus			<0.0001
No ROP	206	5 (2.4%)
Stage 2, zone I	26	6 (23.1%)
Stage 2, zone II	196	11 (5.6%)
Stage 3, zone I	58	14 (24.1%)
Stage 3, zone II	195	18 (9.2%)

PMA, postmenstrual age.