Table 2:

Top up-/ down-regulated serum proteins in SCOT participants vs. controls comparison

Protein name	Gene name	Fold Change	P raw	P FDR	Direction
Growth Hormone	GH1*	3.69	<0.001	<0.001	Upregulated
Ferritin	FTH1	3.04	<0.001	<0.001	Upregulated
C-Reactive Protein	CRP	2.98	<0.001	<0.001	Upregulated
Chromogranin-A	CHGA	2.77	<0.001	<0.001	Upregulated
Macrophage inflammatory protein 3 beta	CCL19*	2.48	<0.001	<0.001	Upregulated
Monocyte Chemotactic Protein 1	CCL2*	2.48	<0.001	<0.001	Upregulated
Myoglobin	MB	2.38	<0.001	<0.001	Upregulated
Monokine Induced by Gamma Interferon	CXCL9*	2.30	<0.001	<0.001	Upregulated
B Lymphocyte Chemoattractant	CXCL13*	2.19	<0.001	<0.001	Upregulated
Prolactin	PRL	2.08	<0.001	<0.001	Upregulated
Lactoylglutathione lyase	GLO1*	0.49	<0.001	<0.001	Down regulated
Neuron-Specific Enolase	ENO2*	0.56	0.002	0.007	Down regulated
Vitamin K-Dependent Protein S	PROS1*	0.56	0.005	0.013	Down regulated
Superoxide Dismutase 1	SOD1	0.65	<0.001	<0.001	Down regulated
Protein S100-A6	S100A6*	0.69	0.002	0.006	Down regulated
Macrophage Migration Inhibitory Factor	MIF	0.71	0.023	0.046	Down regulated
Adiponectin	ADIPOQ	0.72	<0.001	<0.001	Down regulated
Kallikrein-7	KLK7*	0.73	<0.001	<0.001	Down regulated
Insulin like Growth Factor Binding Protein 6	IGFBP6	0.73	<0.001	<0.001	Down regulated
Tetranectin	CLEC3B*	0.75	<0.001	<0.001	Down regulated

Abbreviations: FDR: false discovery rate, FC: Fold Change. Values>1 refer to up-regulated expression of proteins and values<1 refer to down-regulated expression of proteins in relation to the value observed in controls. For example: FC=2.30 is equivalent to an increase of 130% from the reference value. FC=0.65 is equivalent to a decrease of 35% from the reference value.

^*Indicates interferon inducible proteins.