Table 3:

Serum proteins correlating significantly with mRSS at baseline

Protein name	Gene name	Correlation		Adjusted for age, gender
		r	Pᵘ	Partial correlation	P
Alpha 1 Antichymotrypsin ↑	SERPINA3	0.42	0.001	0.42	0.001
NT proBNP ↑	NPPB	0.38	0.002	0.38	0.002
Endostatin ↑	COL18A1	0.37	0.002	0.38	0.002
Osteopontin ↑	SPP1	0.34	0.006	0.38	0.002
Angiopoietin 2 ↑	ANGPT2	0.33	0.005	0.33	0.007
Serum Amyloid P Component	APCS	0.32	0.008	0.32	0.010
Tenascin C ↑	TNC	0.31	0.011	0.32	0.010
Alpha 1 Microglobulin	AMBP	0.31	0.011	0.32	0.012
Insulin like Growth Factor Binding Protein 4 ↑	IGFBP4	0.30	0.018	0.34	0.009
Interleukin 22	IL22	−0.30	0.016	−0.29	0.020
Hepatocyte Growth Factor receptor	MET	−0.30	0.016	−0.31	0.012
Tetranectin ↓	CLEC3B	−0.31	0.011	−0.34	0.007
Kallikrein 5 ↓	KLK5	−0.33	0.007	−0.33	0.007
Urokinase type Plasminogen Activator	PLAU	−0.34	0.005	−0.35	0.005
Thymus and activation regulated chemokine	CCL17	−0.35	0.003	−0.36	0.003
Tamm Horsfall Urinary Glycoprotein	UMOD	−0.40	0.001	−0.42	0.001
Macrophage Derived Chemokine ↓	CCL22	−0.43	<0.001	−0.44	<0.001
Epidermal Growth Factor Receptor ↓	EGFR	−0.43	<0.001	−0.43	0.001

Abbreviations: r: Pearson correlation coefficient; Pᵘ: p value from univariable model; P: p value from multivariable model after adjustment for age and gender

^↑Proteins differentially expressed and upregulated in dcSSc vs. controls;

^↓Proteins differentially expressed down regulated in dcSSc vs. controls