Table 3.
Cytotoxic Activity of Compounds 1–9 Against a Panel of Human Cancer Cells Lines.
| Compound | IC50a values (μM) | ||
|---|---|---|---|
| MDA-MB-435 | MDA-MB-231 | OVCAR3 | |
| 1 | > 25 | > 25 | > 25 |
| 2 | 3.4 | 12 | 13 |
| 3 | 15 | 17 | 18 |
| 4 | 3.6 | 20 | 17 |
| 5 | 3.0 | 12 | 7.9 |
| 6 | 3.2 | 15 | 9.6 |
| 7 | 0.7 | 6.2 | 0.9 |
| 8 | 2.1 | 7.8 | 7.3 |
| 9 | 2.2 | 4.4 | 6.6 |
| Positive controlb | 0.4 nM | 0.2 nM | 5.1 nM |
IC50 values were determined as the concentration required to inhibit growth to 50% of control with a 72 h incubation at 37 °C.
taxol (paclitaxel)