Table 3.

Cytotoxic Activity of Compounds 1–9 Against a Panel of Human Cancer Cells Lines.

Compound	IC50a values (μM)
	MDA-MB-435	MDA-MB-231	OVCAR3
1	> 25	> 25	> 25
2	3.4	12	13
3	15	17	18
4	3.6	20	17
5	3.0	12	7.9
6	3.2	15	9.6
7	0.7	6.2	0.9
8	2.1	7.8	7.3
9	2.2	4.4	6.6
Positive controlb	0.4 nM	0.2 nM	5.1 nM

^aIC₅₀ values were determined as the concentration required to inhibit growth to 50% of control with a 72 h incubation at 37 °C.

^btaxol (paclitaxel)