Box 2:

Major cytokine-based subsets of T cells and macrophages

CD4+ T cell subsets
	Positive	Negative
Th1	IFNγ, IL2, TNFα	IL4
Th2	IL4, IL5, IL9, IL10, IL13, TNFα	IFNγ
Treg	IL4, IL10, TGFβ
Th9	IL9
Th17	IL9, IL17, IL21, IL22	IL4, IFNγ
Th22	IL22	IL4, IFNγ, IL9, IL17
CD8+ T cell subsets
Tc1	IFNγ, IL2,TNFα	IL4, IL5
Tc2	IL5, IL13	IFNγ
Treg	IL10, TGFβ
Tc9	IL9, IL10
Tc17	IL17, IL21
Macrophages
M1	TNFα, IL1β, IL6, IL12, IL23, IL-27
M2a	IL10, TGFβ
M2b	TNFα, IL1β, IL6, IL10
M2c	IL10, TGFβ
M2d	IL10

Overview of the major subsets of CD3⁺ T cells and macrophages based on cytokine production based on references [74] and [75]. There are additional subsets of T cells, including γδ T cells and T cell subsets can be further divided on the basis of e.g. their function as memory, effector or effector memory T cells, but this is beyond the scope.