Table 4.
Univariable and multivariable predictors of all-cause mortality following first cardiac surgery for T21 cohort and euploidic comparators
| Univariable | Multivariable | |||
| Risk Factor | HR (95% CI) | P value | HR (95% CI) | P value |
| T21 | 1.74 (1.39–2.17) | <0.001 | 1.83 (1.46–2.28) | <0.001 |
| Euploidic | Ref | Ref | ||
| Sex | ||||
| Male | 1.16 (0.94–1.44) | 0.159 | 1.15 (0.93–1.43) | 0.196 |
| Female | Ref | Ref | ||
| Age at first surgery | ||||
| < 28 days* | ||||
| ≤ 2 yrs follow-up | 7.31 (4.86–11.00) | <0.001 | 4.64 (2.26–9.53) | <0.001 |
| >2 yrs follow-up | 1.99 (1.08–3.66) | 0.044 | 0.57 (0.26–1.23) | 0.153 |
| 28–364 days* | ||||
| ≤ 2 yrs follow-up | 1.41 (1.00–1.99) | 0.048 | 2.69 (1.50–4.85) | 0.001 |
| > 2 yrs follow-up | 0.77 (0.58–1.02) | 0.071 | 0.74 (0.47–1.16) | 0.192 |
| 1–5 yrs | 0.78 (0.61–0.99) | 0.038 | 1.06 (0.68–1.65) | 0.786 |
| 6–20 yrs | Ref | Ref | ||
| Surgical Era | ||||
| Early 1982–1992 | Ref | Ref | ||
| Middle 1993–1997 | 0.78 (0.63–0.98) | 0.031 | 0.66 (0.50–0.84) | 0.001 |
| Late 1998–2003 | 0.76 (0.56–0.1.02) | 0.062 | 0.53 (0.37–0.76) | 0.001 |
| Initial palliation | 4.87 (3.80–6.24) | <0.001 | 3.09 (2.24–4.27) | <0.001 |
| Complexity Category | ||||
| Simple | Ref | Ref | ||
| Moderate | 1.41 (1.14–1.75) | 0.001 | 1.72 (1.36–2.18) | <0.001 |
| Severe | 4.69 (3.46–6.35) | <0.001 | 2.96 (1.96–4.47) | <0.001 |
| For CAVC | Univariable | Multivariable | ||
| Risk Factor | HR (95% CI) | P value | HR (95% CI) | P value |
| T21 | 1.89 (1.19–3.00) | 0.006 | 2.23 (1.39–3.60) | 0.001 |
| Euploidic | Ref | Ref | ||
| Sex | ||||
| Male | 1.21 (0.78–1.89) | 0.386 | 1.21 (0.77–1.90) | 0.412 |
| Female | Ref | Ref | ||
| Age at first surgery | ||||
| < 28 days | 3.65 (1.59–8.41) | 0.010 | 0.68 (0.15–3.05) | 0.620 |
| 28–264 days | 0.69 (0.42–1.14) | 0.574 | 0.57 (0.17–1.86) | 0.352 |
| 1–5 yrs | 1.03 (0.56–1.90) | 0.926 | 0.78 (0.22–2.79) | 0.706 |
| 6–20 yrs | Ref | Ref | ||
| Surgical Era | ||||
| Early 1982–1992 | Ref | Ref | ||
| Middle 1993–1997 | 0.72 (0.46–1.12) | 0.147 | 0.44 (0.29–0.75) | 0.002 |
| Late 1998–2003 | 0.46 (0.24–0.90) | 0.013 | 0.35 (0.16–0.76) | 0.008 |
| Initial palliation | 6.84 (4.23–11.07) | <0.001 | 7.07 (4.03–12.42) | <0.001 |
Reported are hazard ratio (HR) and 95% confidence intervals for multivariable Cox regression.
*
Proportional hazards assumption was violated and follow-up duration cut points were created based on survival curve.
Ref = reference category; T21 = Trisomy 21; CAVC = common atrioventricular canal; PPM = permanent pacemaker; LAVV = left atrioventricular valve