Table 2.

Sensitivity, specificity and AUC of CRP/ALB ratios in predicting surgery and mortality in neonates with radiologically confirmed, non-perforated NEC

Outcomes	CRP/ALB ratio	Sensitivity (95% CI)	Specificity (95% CI)	AUC (95% CI)	p =
Surgery	Day 1 (n = 158)
	CRP/ALB ratio ≥ 2	43.9 (32.6–55.9)	76.1 (66.4–83.6)	0.60 (0.51–0.69)	0.032
	CRP/ALB ratio ≥ 2.5	43.9 (32.6–55.9)	76.1 (66.4–83.6)	0.60 (0.51–0.69)	0.032
	CRP/ALB ratio ≥ 3	39.4 (28.5–51.5)	78.3 (68.8–85.5)	0.59 (0.50–0.68)	0.059
	Day 2 (n = 170)
	CRP/ALB ratio ≥ 2	78.4 (67.7–86.2)	56.3 (46.3–65.7)	0.67 (0.59–0.76)	< 0.001
	CRP/ALB ratio ≥ 2.5	75.7 (53.6–72.5)	63.5 (53.6–72.5)	0.70 (0.62–0.78)	< 0.001
	CRP/ALB ratio ≥ 3	70.3 (59.1–79.5)	68.1 (58.0–76.8)	0.71 (0.63–0.79)	< 0.001
	Day 3 (n = 146)
	CRP/ALB ratio ≥ 2	81.2 (69.7–89.8)	50.6 (40.5–60.6)	0.66 (0.57–0.75)	0.001
	CRP/ALB ratio ≥ 2.5	80.0 (67.6–88.5)	60.4 (50.2–69.9)	0.70 (0.62–0.79)	< 0.001
	CRP/ALB ratio ≥ 3	76.4 (63.7–85.6)	71.9 (62.2–79.9)	0.72 (0.64–0.81)	< 0.001
Mortality	Day 1 (n = 158)
	CRP/ALB ratio ≥ 2	31.8 (16.4–52.7)	67.7 (59.4–74.9)	0.50 (0.37–0.63)	0.968
	CRP/ALB ratio ≥ 2.5	31.8 (16.4–52.7)	67.7 (59.4–74.9)	0.50 (0.37–0.63)	0.968
	CRP/ALB ratio ≥ 3	31.8 (16.4–52-7)	57.8 (49.7–65.5)	0.52 (0.38–0.65)	0.813
	Day 2 (n = 170)
	CRP/ALB ratio ≥ 2	78.3 (58.1–90.3)	44.2 (36.4–52.3)	0.61 (0.50–0.73)	0.083
	CRP/ALB ratio ≥ 2.5	73.9 (53.5–87.5)	49.7 (41.7–57.7)	0.62 (0.50–0.74)	0.069
	CRP/ALB ratio ≥ 3	73.9 (53.3–87.5)	71.3 (63.2–78.3)	0.66 (0.54–0.77)	0.015
	Day3 (n = 146)
	CRP/ALB ratio ≥ 2	76.5 (52.7–90.5)	40.3 (32.2–48.9)	0.58 (0.45–0.72)	0.262
	CRP/ALB ratio ≥ 2.5	76.5 (52.7–90.5)	48.1 (39.6–56.6)	0.62 (0.49–0.76)	0.101
	CRP/ALB ratio ≥ 3	70.6 (46.9–86.7)	54.3 (45.7–62.6)	0.62 (0.49–0.76)	0.096