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. 2021 Mar 15;12:638215. doi: 10.3389/fphar.2021.638215

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Copyright © 2021 Zhang, Mao, Gu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SC significantly delayed wound healing of HRMECs. The scratch-wound assay was performed on monolayer HRMECs cultures using a 1 ml pipet tip. (A) Representative photographs were captured at 0 and 24 h after wounding. The migration distances of HRMECs at the edge of the scratch wound were recorded under microscope. (B) Quantification analysis of HRMECs migration rates. The migration distance of SC treated group was significantly less than the untreated (Ctrl) group, ***p < 0.001 vs. control group. The results represent the mean ± SEM (n = 3) of one-way ANOVA followed by Tukey’s posthoc multiple comparison tests.