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. 2021 Mar 15;12:638215. doi: 10.3389/fphar.2021.638215

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Copyright © 2021 Zhang, Mao, Gu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SC suppressed the expression of VEGF in retina/choroid complex. The (A) Immunoblotting of VEGF expression in the retina/choroid complexes was performed 7 days after laser injury with or without the treatment of SC (2.5 μM, 2 μl/eye). The group without laser injury and SC was set as control group. (n = 18 eyes/group) (B) Relative expressions of VEGF to β-actin. (C) VEGF protein level normalized to total protein concentration measured by ELISA assay in the retina-choroid complex at the same time point with the immunoblotting analysis. Pretreatment of SC significantly decrease the VEGF expression in the laser site. Data were presented as the mean ± SEM and analyzed using a one-way ANOVA followed by Bonferroni’s posthoc multiple comparison tests. *p < 0.05 vs. the laser group.