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. 2021 Mar 15;15:648624. doi: 10.3389/fncir.2021.648624

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Copyright © 2021 Vijayraghavan and Everling.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic showing the localization of muscarinic receptors on PFC neurons and their relationship to cholinergic and glutamatergic innervation based on data from Mrzljak et al. (1993) and Medalla and Barbas (2012). M1Rs are localized on dendritic shafts of pyramidal and interneurons, and on the spines of pyramidal neurons where they are apposed to glutamatergic synapses. Cholinergic synapses are mainly found on dendritic shafts, while extrasynaptic cholinergic release sites on cholinergic axons result in diffuse volume transmission to influence muscarinic receptors on PFC neurons. M2Rs are found on postsynaptic dendritic spines of pyramidal neurons and on dendritic shafts of interneurons. M2Rs are also found on presynaptic terminals of glutamatergic afferents in PFC and as autoreceptors on cholinergic terminals.