Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 15;8:639541. doi: 10.3389/fcvm.2021.639541

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Qiu, Zhang, Li, Jiang, Guo, He and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

DON reduced M2-macrophage phenotype in BMDMs. BMDMs from the three groups were isolated. After purified and cultured, the biomarkers of M2-macrophage and inflammatory factors of BMDMs were identified by real time-PCR. (A) Quantitative analysis of relative mRNA expression of Arg-1. (B) Quantitative analysis of relative mRNA expression of MRC1. (C) Quantitative analysis of relative mRNA expression of Fizz1. (D) Quantitative analysis of relative mRNA expression of IL-6. (E) Quantitative analysis of relative mRNA expression of TNF-α. Arg-1, argirase-1; BMDMs, bone marrow-derived macrophages; Ctrl, control; DON, donepezil; Fizz1, found in inflammatory zone 1; IL-6, interleukin-6; MCT, monocrotaline; MRC1, mannose receptor-1; TNF-α, tumor necrosis factor-α. *P < 0.05, vs. Ctrl group, ^#P < 0.05, vs. MCT group (n = 5).