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. 2021 Mar 15;9:657305. doi: 10.3389/fcell.2021.657305

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Copyright © 2021 Chen, Geng, Syeda, Huang, Zhang and Ying.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MUS81 sustains survival of BRCA2-deficient cancer cells through rescuing reversed forks. (A) The mechanism of MUS81 resolving chromosomal interlinks in cells lacking BRCA2. (B) MUS81 is dispensable in BRCA1-deficient cells.