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. 2021 Mar 15;12:595702. doi: 10.3389/fgene.2021.595702

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Copyright © 2021 Ngo-Bitoungui, Belinga, Mnika, Masekoameng, Nembaware, Essomba, Ngo-Sack, Awandare, Mazandu and Wonkam.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The subnetwork extracted from the human PPI network revealing how predicted gene variants interact together to influence the kidney dysfunction (refer to Table 4 for gene descriptions). In yellow and magenda are gene variants previously shown to be associated with kidney-dysfunction, three in magenda color have been confirmed. In green color, are intermediate nodes used by kidney-dysfunction gene variants to reach the one in red color (NFKB1) indicated to be essential in the PPI network.