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. 2021 Mar 15;12:638885. doi: 10.3389/fphar.2021.638885

FIGURE 1.

FIGURE 1

(A,B) Haemolytic and recovery responses to high (adult dose 30 mg) and low (adult dose 15 mg) daily primaquine doses in males with presumed G6PD*A- deficiency (A) is replotted from Hockwald et al. (1952). This figure shows haemoglobin values in five healthy G6PD deficient males that developed acute haemolytic anaemia when taking PQ 30 mg daily. Dosing was stopped early before completing the 14-day course. After haemoglobin recovery to steady state (duration of time not reported) the same subjects were given PQ 15 mg daily for 14 days. The smaller symbol size represents the low (15 mg) daily PQ dose. Figure 1B is replotted from Dern et al. (1954) and Dern et al. (1955), and Kellermeyer et al. (1961). This figure shows haemoglobin values in healthy G6PD deficient males receiving continuous daily doses of primaquine (PQ) 30 mg (black) and sulfanilamide 3.6 mg (green). The lines end when dosing was stopped, except in one person continuing to day 50 (triangle symbol), see Figure 2. The symbols identify the same subjects in Figure 2.