Table 2.
Genotype frequency distribution of MRP4 in KD cases.
| Genotype | IVIG-R (n = 148) |
IVIG-S (n = 612) |
pa | OR (95% CI) | p | Adjusted OR (95% CI) | Adjusted pb |
|---|---|---|---|---|---|---|---|
| rs1751034 T/C | |||||||
| TT | 82 (55.41) | 387 (63.24) | 0.0441 | 1.00 | 1.00 | ||
| TC | 54 (36.49) | 203 (33.17) | 1.26 (0.86–1.84) | 0.2446 | 1.26 (0.86–1.84) | 0.2427 | |
| CC | 12 (8.11) | 22 (3.59) | 2.57 (1.23–5.41) | 0.0126 | 2.54 (1.21–5.34) | 0.0143 | |
| Dominant | 66 (44.59) | 225 (36.76) | 0.0807 | 1.38 (0.96–1.99) | 0.0793 | 1.38 (0.96–1.99) | 0.0803 |
| Recessive | 136 (91.89) | 590 (96.41) | 0.0268 | 2.37 (1.14–4.90) | 0.0203 | 2.33 (1.12–4.83) | 0.0230 |
| rs3742106 A/C | |||||||
| AA | 30 (20.27) | 139 (22.71) | 0.4010 | 1.00 | 1.00 | ||
| AC | 80 (54.05) | 293 (47.88) | 1.27 (0.79–2.02) | 0.3223 | 1.27 (0.80–2.02) | 0.3190 | |
| CC | 38 (25.68) | 180 (29.41) | 0.98 (0.58–1.66) | 0.9346 | 0.97 (0.57–1.65) | 0.9215 | |
| Dominant | 118 (79.73) | 473 (77.29) | 0.5179 | 1.16 (0.74–1.80) | 0.5217 | 1.16 (0.74–1.80) | 0.5236 |
| Recessive | 110 (74.32) | 432 (70.59) | 0.3631 | 0.83 (0.55–1.25) | 0.3676 | 0.83 (0.55–1.24) | 0.3551 |
| rs9561778 G/T | |||||||
| GG | 70 (47.30) | 307 (50.16) | 0.8199 | 1.00 | 1.00 | ||
| GT | 67 (45.27) | 261 (42.65) | 1.13 (0.78–1.64) | 0.5339 | 1.12 (0.77–1.63) | 0.5494 | |
| TT | 11 (7.43) | 44 (7.19) | 1.10 (0.54–2.23) | 0.7994 | 1.08 (0.53–2.20) | 0.8301 | |
| Dominant | 78 (47.30) | 307 (50.16) | 0.5313 | 1.12 (0.78–1.61) | 0.5316 | 1.11 (0.78–1.60) | 0.5529 |
| Recessive | 137 (92.57) | 568 (92.81) | 0.9187 | 1.04 (0.52–2.06) | 0.9177 | 1.02 (0.51–2.04) | 0.9478 |
| rs3765534 C/T | |||||||
| CC | 131 (88.51) | 556 (90.85) | 0.4931 | 1.00 | 1.00 | ||
| CT | 16 (10.81) | 55 (8.99) | 1.24 (0.69–2.22) | 0.4825 | 1.26 (0.70–2.28) | 0.4398 | |
| TT | 1 (0.68) | 1 (0.16) | 4.24 (0.26–68.30) | 0.3078 | 4.64 (0.29–75.21) | 0.2801 | |
| Dominant | 17 (11.49) | 56 (9.15) | 0.3964 | 1.29 (0.73–2.29) | 0.3877 | 1.32 (0.74–2.35) | 0.3488 |
| Recessive | 147 (99.32) | 611 (99.84) | 0.3333 | 4.16 (0.26–66.84) | 0.3148 | 4.51 (0.28–72.97) | 0.2892 |
| rs868853 T/C | |||||||
| TT | 107 (72.30) | 417 (68.14) | 0.6126 | 1.00 | 1.00 | ||
| TC | 38 (25.68) | 181 (29.58) | 0.82 (0.54–1.23) | 0.3365 | 0.82 (0.55–1.24) | 0.3486 | |
| CC | 3 (2.03) | 14 (2.29) | 0.84 (0.24–2.96) | 0.7801 | 0.82 (0.23–2.91) | 0.7571 | |
| Dominant | 41 (27.70) | 195 (31.86) | 0.3224 | 0.82 (0.55–1.22) | 0.3269 | 0.82 (0.55–1.22) | 0.3345 |
| Recessive | 145 (97.97) | 598 (97.71) | 0.8456 | 0.88 (0.25–3.12) | 0.8476 | 0.87 (0.25–3.05) | 0.8213 |
| rs7320375 A/G | |||||||
| AA | 97 (65.54) | 382 (62.42) | 0.5861 | 1.00 | 1.00 | ||
| AG | 43 (29.05) | 203 (33.17) | 0.83 (0.56–1.24) | 0.3713 | 0.84 (0.56–1.25) | 0.3840 | |
| GG | 8 (5.41) | 27 (4.41) | 1.17 (0.51–2.65) | 0.7121 | 1.18 (0.52–2.67) | 0.7004 | |
| Dominant | 51 (34.46) | 230 (37.58) | 0.4785 | 0.87 (0.60–1.27) | 0.4803 | 0.88 (0.60–1.28) | 0.4959 |
| Recessive | 140 (94.59) | 585 (95.59) | 0.6118 | 1.24 (0.55–2.78) | 0.6053 | 1.25 (0.55–2.81) | 0.5949 |
| Combined effect of risk genotypes | |||||||
| 0–2 | 84 (56.76) | 409 (66.83) | 0.0227 | 1.00 | 1.00 | ||
| 3–6 | 64 (43.24) | 203 (33.17) | 1.52 (1.05–2.22) | 0.0283 | 1.52 (1.04–2.22) | 0.0295 | |
a
Two-sided χ2 test for distributions between Kawasaki disease patients with IVIG resistance and IVIG sensitivity.
b
Adjusted for age and gender status in logistic regress models.
Bold values indicate value of p less than 0.05.