Table 1.

Antitubercular agents inhibiting mycolylarabinogalactan peptidoglycan (mAGP) assembly.

No.	Target	Scaffold	SAR plan from hit	Most advanced analogue	In vivo efficacy	Ref.
1.1	DprE1	4−Aminoquinolone piperidine amides			N/Da	(Naik et al., 2014)
1.2		Pyrazolopyridones			N/D	(Panda et al., 2014)
1.3		2-Carboxy quinoxalines			N/D	(Neres et al., 2015)
1.4		5-Hydroxy pyrimidinediones			N/D	(Oh et al., 2018)
2.1	MmpL3	Adamantyl ureas			N/D	(Brown et al., 2011; North et al., 2013)
2.2		Indolecarboxamides			Yesb	(Onajole et al., 2013; Stec et al., 2016)
2.3					Yesb	(Kondreddi et al., 2013)
2.4		Tetrahydropyrazolo pyrimidine carboxamide			Yesb	(Remuinan et al., 2013; Yokokawa et al., 2013)
2.5		Spirocycles			Yesb	(Remuinan et al., 2013; Guardia et al., 2018)
3.1	MurI	Benzoxazoles			Yesc	(Malapati et al., 2018)

^aN/D, not determined; ^bYes, active in an acute TB infection mouse model; ^c Yes, active in Mycobacterium marinum infected adult zebrafish model.