Table 3.

Antitubercular agents inhibition the mycobacterial respiratory system.

No.	Target	Scaffold	SAR plan from hit	Most advanced analogue	In vivo efficacy	Ref.
1.1	NDH-2	Quinolinyl pyrimidines			N/Da	(Shirude et al., 2012)
1.2		Quinolones			N/D	(Hong et al., 2017)
1.3		2−Mercapto quinazolinones			N/D	(Murugesan et al., 2018)
1.4					N/D	(Harbut et al., 2018)
2.1	QcrB	Alkyl benzimidazoles			N/D	(Chandrasekera et al., 2015; Chandrasekera et al., 2017)
2.2		Morpholino thiophenes			Yesb	(Cleghorn et al., 2018)
3.1	MenG	Biphenyl amides			N/D	(Sukheja et al., 2017)

^aN/D, not determined; ^bYes, active in an acute TB infection mouse model.