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SIRT3 treatment moderated Ti particle-induced bone destruction and enhanced bone formation in a periprosthetic osteolysis rat model. (A) Representative images of Micro-CT. (B) BMD (mg/mm3). (C) Conn.D (mm−3). (D) BV/TV (%). (E) BS/BV (mm−1). (F) Tb.N (mm−1). (G) Tb.Th (mm). (H) Tb.Sp (mm). (I) Max fixation strength (N) identified by biomechanical evaluation. (n = 6 per group. Values are shown as the means ± s.d. *p < 0.05 and **p < 0.01).
