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miR-29b inhibits the TGF-β1/Smad3 signaling pathway by directly targeting TGF-β1. (A) Sequence of the binding sites of miR-29b on the 3'-UTR of TGF-β1 predicted using TargetScan. (B) Significantly lower luciferase activity was observed with the wild-type TGF-β1 sequence compared with the control and mutant. *P<0.05 vs. EV (n=6). EV, empty vector; miR, microRNA; mut, mutant; TGF-β1, transforming growth factor β1; 3'-UTR, 3'-untranslated region; WT, wild-type.
