Table 4.

miRNA polymorphisms and risk of AD.

microRNA	Polymorphism	Samples	Population	Assay method	Function	References
miR-138	Copy number variant (CNV)	Whole exome sequencing data of 546 unrelated patients with early-onset Alzheimer's disease (EOAD) and 597 controls subjects	French	QMPSF	Its duplication was observed in EOAD patients and functional studies showed that miR-138 upregulation caused increased production of Aβ and higher phosphorylation of tau. So miR-138 gene dosage can be a potential risk factor for EOAD.	Boscher et al., 2019
Pri-miR-146a	SNP (rs2910164)	Blood samples from 103 AD patients and 206 healthy controls	Han Chinese	Sequencing	Rare C allele of this SNP was correlated AD and low expression of mature miR-146a-5p.	Zhang et al., 2015
miR-146a	SNP (rs57095329)	Blood samples from 292 AD patients 300 healthy volunteers	Chinese	ABI PRISM SNapShot method	AA genotype of rs57095329 was correlated with an elevated predisposition to AD and was associated with high expression of miR-146a.	Cui et al., 2014
miR-1229 precursor	SNP (rs2291418)	Analysis of GWAS data on late-onset AD	-	-	rs2291418 was associated with AD risk. An allele of rs2291418 was correlated with an increased miR-1229-3p expression that targets an AD-related gene, SORL1, so can have an important role in AD.	Ghanbari et al., 2016