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. 2021 Mar 15;12:608625. doi: 10.3389/fimmu.2021.608625

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Copyright © 2021 Rohrbacher, Brauchle, Ogrinc Wagner, von Bergwelt-Baildon, Bücklein and Subklewe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of PI3K∂ by idelalisib decreases NK-cell cytotoxicity. (A,B) Cytotoxicity of CD3^negCD56^pos NK cells against the K562 cell line in a standard calcein-release assay and against the Jurkat cell line in a flow cytometry-based coculture assay. Error bars represent mean ± SEM; *p ≤ 0.05, **p ≤ 0.005; n = 12 HDs.