Table 2.
Proteins or peptides providing potential modification targets to load therapeutic agents.
| Proteins or peptides | Characteristics | reference |
|---|---|---|
| CD63, CD9, CD81 | Tetraspanin | (194–196) |
| MHC | Membrane-anchored | (197) |
| SCAMPs | Secretory carrier-associated membrane protein | (193) |
| EGF VIII | Transmembrane glycoprotein | (198) |
| LAMP2B, LAMP1 | Lysosome-associated membrane glycoprotein 2, lysosome-associated membrane glycoprotein 1 | (199, 200) |
| PDGFR TM domain | Cell surface tyrosine kinase receptor | (201) |
| VSVG | Vesicular stomatitis virus glycoprotein | (185) |
| HSP90, HSP70, HSP50 | Heat shock protein | (202, 203) |
| WW tag | Recognized by the L-domain-containing protein Ndfip1, resulting in ubiquitination and loading into sEVs | (189) |
| ALIX-1 | Cytosolic protein that associates with MVB by interacting with ESCRT-III subunit SNF7 | (204) |