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Expression of Bcl2 and BAX genes in 2 and 3D cultures of MCF-7 treated under different conditions. Expression of (A) Bcl2 and (B) BAX in cells treated with curcumin, FAC or combined treatment for 48 h. Expression of (C) Bcl2 and (D) BAX in cells treated with 2 Gy, 8 Gy RAD either alone or combined with curcumin for 48 h. Results are presented as mean ± SD (n=5) *P<0.001 vs. control; #P<0.001 2D vs. 3D culture. Cur, curcumin; FAC, 5-Fluorouracil-Adriamycin-cyclophosphamide.
