Table 1.
Main characteristics of the study population.
| Variable | Overall | Non screen detected | Screen detected | p-value° | ||||
|---|---|---|---|---|---|---|---|---|
| N | %* | N | %* | N | %* | |||
| Total (row %) | 1,360 | 100 | 896 | 65.9 | 464 | 34.1 | ||
| Year of diagnosis | 2006–2009 | 71 | 5.2 | 67 | 7.5 | 4 | 0.9 | <0.0001 |
| 2010–2013 | 595 | 43.8 | 377 | 42.1 | 218 | 47 | ||
| 2014–2018 | 694 | 51 | 452 | 50.4 | 242 | 52.2 | ||
| Sex | Men | 803 | 59 | 539 | 60.2 | 264 | 56.9 | 0.25 |
| Women | 557 | 41 | 357 | 39.8 | 200 | 43.1 | ||
| Age (years) | 50–59 | 518 | 38.1 | 332 | 37.1 | 186 | 40.1 | 0.27 |
| 60–69 | 842 | 61.9 | 564 | 62.9 | 278 | 59.9 | ||
| ASA score | 1–2 | 691 | 82.9 | 429 | 79.3 | 262 | 89.4 | 0.0001 |
| 3–4 | 143 | 17.1 | 112 | 20.7 | 31 | 10.6 | ||
| Missing | 526 | (38.7) | 355 | (39.6) | 171 | (36.9) | ||
| Body Mass Index | <25 | 438 | 43.9 | 317 | 45.8 | 121 | 39.7 | 0.19 |
| 25–30 | 398 | 39.9 | 268 | 38.7 | 130 | 42.6 | ||
| ≥30 | 161 | 16.1 | 107 | 15.5 | 54 | 17.7 | ||
| Missing | 363 | (26.7) | 204 | (22.8) | 139 | (30.0) | ||
| Comorbidities | Yes | 583 | 59.7 | 411 | 62.4 | 172 | 54.1 | 0.0134 |
| No | 394 | 40.3 | 248 | 37.6 | 146 | 45.9 | ||
| Missing | 383 | (28.2) | 237 | (26.5) | 146 | (31.5) | ||
| Tumor Site | Colon, proximal | 491 | 36.2 | 298 | 33.3 | 193 | 41.9 | 0.0018 |
| Colon, distal | 422 | 31.1 | 276 | 30.9 | 146 | 31.7 | ||
| Rectum | 418 | 30.8 | 298 | 33.3 | 120 | 26 | ||
| Not specified or multiple | 24 | 1.8 | 22 | 2.5 | 2 | 0.4 | ||
| Missing | 5 | (0.4) | 2 | (0.2) | 3 | (0.6) | ||
| pTNM staging | 0 | 83 | 6.5 | 52 | 6.3 | 31 | 6.9 | <0.0001 |
| 1 | 400 | 31.3 | 189 | 22.8 | 211 | 47.1 | ||
| 2 | 270 | 21.2 | 179 | 21.6 | 91 | 20.3 | ||
| 3 | 324 | 25.4 | 228 | 27.5 | 96 | 21.4 | ||
| 4 | 199 | 15.6 | 180 | 21.7 | 19 | 4.2 | ||
| Missing | 84 | (6.2) | 68 | (7.6) | 16 | (3.4) | ||
| Grading | 1 | 114 | 12.4 | 62 | 10.2 | 52 | 16.9 | 0.0004 |
| 2 | 641 | 70 | 418 | 68.8 | 223 | 72.4 | ||
| 3 | 160 | 17.5 | 127 | 20.9 | 33 | 10.7 | ||
| 4 | 1 | 0.1 | 1 | 0.2 | 0 | 0 | ||
| Missing | 444 | (32.6) | 288 | (32.1) | 156 | (33.6) | ||
| Lymphatic invasion | Yes | 223 | 32.1 | 163 | 36.2 | 60 | 24.6 | 0.0017 |
| No | 471 | 67.9 | 287 | 63.8 | 184 | 75.4 | ||
| Missing | 666 | (49.0) | 446 | (49.8) | 220 | (47.4) | ||
| Vascular invasion | Yes | 417 | 48.5 | 306 | 54.2 | 111 | 37.8 | <0.0001 |
| No | 442 | 51.5 | 259 | 45.8 | 183 | 62.2 | ||
| Missing | 501 | (36.8) | 331 | (36.9) | 170 | (36.6) | ||
| Perineurial invasion | Yes | 259 | 29.1 | 205 | 35.2 | 54 | 17.6 | <0.0001 |
| No | 631 | 70.9 | 378 | 64.8 | 253 | 82.4 | ||
| Missing | 470 | (34.6) | 313 | (34.9) | 157 | (33.8) | ||
| Resection margin status | R0 | 1186 | 89.8 | 754 | 86.8 | 432 | 95.6 | <0.0001 |
| R1 | 23 | 1.7 | 20 | 2.3 | 3 | 0.7 | ||
| R2 | 112 | 8.5 | 95 | 10.9 | 17 | 3.8 | ||
| Missing | 39 | (2.9) | 27 | (3.0) | 12 | (2.6) | ||
| Neoadjuvant therapy | Yes (rectum) | 182 | 14.3 | 152 | 18.4 | 30 | 6.7 | <0.0001 |
| Yes (colon) | 44 | 3.5 | 42 | 5.1 | 2 | 0.4 | ||
| Yes (not specified or multiple) | 3 | 0.2 | 3 | 0.4 | 0 | 0 | ||
| No | 1042 | 82 | 628 | 76.1 | 414 | 92.8 | ||
| Missing | 89 | (6.5) | 71 | (7.9) | 18 | (3.9) | ||
| Adjuvant therapy | Yes | 524 | 47.5 | 381 | 55.5 | 143 | 34.3 | <0.0001 |
| No | 579 | 52.5 | 305 | 44.5 | 274 | 65.7 | ||
| Missing | 257 | (18.9) | 210 | (23.4) | 47 | (10.1) | ||
*Percentages are computed on patients with available data. Percentage of missing data are computed on all patients.
°χ2 test was used.
ASA, American Society of Anesthesiologists.