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. 2021 Mar 15;11:616918. doi: 10.3389/fcimb.2021.616918

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Copyright © 2021 Fitzgerald, Shkoporov, Upadrasta, Khokhlova, Ross and Hill

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fifty six strongly enriched viral contigs represent diverse members of the order Caudovirales and replicated in the presence of typical human gut bacteria. (A) Z-scores of relative abundance of 56 manually selected viral genomic contigs across all study samples. Specific enrichment in one or a few related strains is a typical result. (B) Heatmap of scaled and centred relative abundance of 56 contigs across all 128 samples. (C) Circular genome of 35.3 kb Bacteroides uniformis DSM6597 phage; (D) circular genome of 46.4 kb temperate Siphoviridae phage infecting Anaerostipes hadrus APC942/1; (E) circular genome of a 168.6 kb E. coli phage; (F) circular genome of a 40.3 kb Subdoligranulum sp. APC924/74 inducible prophage; (G) circular genome of a 104.9 kb crAss-like phage of Prevotella stercorea DSM 18206.