Table 2.
Safety, efficacy, and time course of anesthesia after administration three anesthetic protocols to perform portal vein infection with Echinococcus granulosus s. l. protoscoleces in female CF-1 mice.
| Protocols | (1) K 80/X 8 | (2) Pre-anesthetics + K 80/X 8 | (3) Pre-anesthetics + K 80/X 8 + Y |
|---|---|---|---|
| Loss of Reflexesa | 3/8 | 6/6 | 8/8 |
| Induction Time (min) | 8 (2,5)∗ | 3 (0.75) | 3 (0) |
| Survivalb | 2/3 | 4/6 | 8/8 |
| Recovery Time (min) | 68.5 (35.5) | 54 (14.25) | 28.5 (9.75)∗∗ |
| Duration of action (min) | 80.5 (36.5) | 66 (14.25) | 40.5 (11.25)∗∗ |
K: ketamine, X: xylazine, Pre-anesthetic (tramadol and atropine), Y: yohimbine.
Time course data are given in minutes and present as median (interquartile range).
(∗) P < 0.05, statistically significant differences between protocol 1 vs. protocols 2 and 3.
(∗∗) P = 0.0005, statistically significant differences between protocol 2 vs. protocols 3.
a
N° of mice that lose reflexes after the administration of the anesthetic cocktail/total n° of mice in the group.
b
N° of recovered mice after surgery/total n° of operated mice.