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. 2021 Jan 10;11(5):1251–1266. doi: 10.1016/j.jcmgh.2020.12.008

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Deletion of SHH in the G cells does not modulate gastrin expression. Representative (A) hematoxylin and eosin images and (B) immunofluorescent images of gastric antrum stained with gastrin (green) and Ki67 (red) from WT and GastCreERT2:Shh^FL/FL mice at the indicated times post tamoxifen injection. Nuclei stained with DAPI (blue). Scale bars = 100 μm. (C) Serum gastrin levels and (D) SHH levels in whole stomach were determined by ELISA. (E) Gli1 mRNA and (F) Gli2 mRNA in the antrum of WT and GastCreERT2/Shh^FL/FL mice were quantified by qPCR. N = 5 mice per time point. Horizontal lines represent the median and interquartile range.