Figure 7.

IL1β overexpression elongates primary cilia and induces Gli2 in vivo. (A) Representative immunofluorescent images of the gastric antrum immunostained for primary cilia (Ac-Tub, red), gastrin (green), and E-cadherin (blue) from WT and GastrinCreERT2/TetOn-hIL-1β mice. Cilia were identified in gastrin⁺ cells (arrows). Scale bars = 10 μm. (B) The antrum was analyzed for GLI2, KIF3A, and GAPDH protein by Western blot. Shown are the levels in 3 mice per group, time point 6 months after tamoxifen treatment.