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Routes of administration validated for PS ASOs
| A. Local administration | ||
|---|---|---|
| Route | Example | Indication |
| Intradermal | Ionis CTGF ASO | Scarring |
| Intravitreal | Vitravene | CMV retinitis |
| Pulmonary | ENAC-2.5 | Cystic fibrosis (CF) |
| Intrathecal | Nusinersen | Spinal Muscular Atrophy |
| Rectal | Alicaforsen | Pouchitis |
| B. Systemic | ||
|---|---|---|
| Route | Example | Indication |
| Subcutaneous | Inotersen | TTR Amyloidosis |
| Subcutaneous, intramuscular | IONIS HCV ASO | Hepatitis C |
| Subcutaneous, oral | Mipomersen | Homozygous Familial Hypercholesterolemia |
