Sedimentation coefficient and diffusion coefficient scaling factors for fractionated VWF/fVIII complexes. (closed circles) and (open circles) versus M values for A280 data (red symbols) and interference data (blue symbols) (Table 1) are plotted on logarithmic scales along with linear regression lines. The units of Dz are Ficks (1 F = 10–7 cm2/s). The slopes and 95% confidence limits for the A280 sw and Dz regressions are 0.51 (0.49,0.53) and –0.49 (–0.47,–0.51), respectively. The corresponding values for the interference regressions are 0.50 (0.48,0.52) and –0.50 (–0.48,–0.52), respectively.