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Scaling factors for globular proteins compared to VWF/fVIII complexes. Sedimentation coefficients, molecular weights, and partial specific volumes for a series of globular proteins (open black circles) are listed in Table S1. The slope of the regression line for globular proteins is 0.65. The data for VWF/fVIII (closed red circles) are derived from A280 SV AUC data (Table 1). Data for the VWF A1 domain (red triangle) is from (63).
