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. 2021 Mar 11;7(1):21. doi: 10.3390/ncrna7010021

Figure 3.

Figure 3

LncRNAs regulate pre-mRNA splicing through an RNA-DNA interaction. In Arabidopsis thaliana, when the SEP3 gene is transcribed, exon 6 can be back-spliced into a circular RNA (SEP3 exon 6 circRNA, yellow) which interacts directly with its parental genomic locus. By forming RNA–DNA hybrids (R-loops), SEP3 exon 6 circRNA favors exon-6 skipping of its linear cognate and promotes the SEP3.3 mRNA (light blue) isoform accumulation which in turn affects flowering time.