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Long noncoding RNAs forming RNA–RNA pairs in the nucleus. Long noncoding (lnc) RNAs can form RNA pairs (dsRNA) with complementary mRNAs in cis (cis-NATs) or in trans (trans-NATs), leading to RNA degradation or to the formation of functional small (sm) RNAs. In addition, antisense transcripts can locally recruit protein partners that modulate the transcriptional activity of overlapping protein-coding genes. Examples of characterized lncRNAs are indicated at the bottom.
